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saxagliptin hydrate

CAS號	945667-22-1
規格	5mg10mg	純度	98%
貨號	HY-10285A	貨期	3天
品牌	Medchemexpress	庫存	需咨詢
規格	5mg10mg
純度	98%
貨號	HY-10285A
貨期	3天
品牌	Medchemexpress
庫存	---
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參考價：￥1200.00 元/5mg

立即詢盤

貨號	品牌	純度	規格	參考價	貨期
HY-10285A	Medchemexpress	98%	5mg10mg	￥1200.00元/5mg	3天

產品詳情

詳細信息(中文)：
Saxagliptin H2O(BMS477118 H2O)是選擇性可逆的DPP4抑制劑，IC50和Ki分別為26 nM和1.3 nM。

詳細信息(英文)：
產品描述：Saxagliptin (hydrate)Saxagliptin H2O(BMS477118 H2O) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM and Ki of 1.3 nM._x000D_ IC50 value: 26 nM [1]_x000D_ Target: DPP4_x000D_ in vitro: Saxagliptin has an inhibition constant Ki of 1.3 nM for DPP4 inhibition, which is 10-fold more potent than either vildagliptin or sitagliptin (another two DPP4 inhibitors) with Ki of 13 and 18 nM. In addition, Saxagliptin demonstrates greater specificity for DPP4 than for either the DPP8 or DPP9 enzymes (400- and 75- fold, respectively). The active metablite of saxagliptin is two-fold less potent than the parent. Both Saxagliptin and its metabolite are highly selective (>4000-fold) for the prevention of DPP4 compared with a range of other proteases (selectivity of sitagliptin and vildagliptin for DPP4 is >2600 and