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4-N-(9-ethylcarbazol-3-yl)-2-N-(3-morpholin-4-ylpropyl)pyrimidine-2,4-diamine

CAS號	1380432-32-5
規格	10mg50mg	純度	98%
貨號	HY-12810	貨期	3天
品牌	Medchemexpress	庫存	需咨詢
規格	10mg50mg
純度	98%
貨號	HY-12810
貨期	3天
品牌	Medchemexpress
庫存	---
注意：請務必與賣家聯系核實單價庫存，以確保您的資金安全及交易順利。
參考價：￥700.00 元/10mg

立即詢盤

貨號	品牌	純度	規格	參考價	貨期
HY-12810	Medchemexpress	98%	10mg50mg	￥700.00元/10mg	3天

產品詳情

詳細信息(中文)：
EHop-016是Rac GTPase高效選擇性抑制劑，在MDA-MB-435細胞中IC50值1.1uM。

詳細信息(英文)：
產品描述：EHop-016EHop-016 is a novel potent and selective inhibitor of Rac GTPase; inhibits Rac1 activity in MDA-MB-435 cells with an IC50 of 1.1 uM._x000D_ IC50 value: 1.1 uM (MDA-MB-435 cell) [1]_x000D_ Target: Rac1 inhibitor_x000D_ in vitro: The IC(50) of 1.1 μM for Rac inhibition by EHop-016 is ～100-fold lower than for NSC23766. EHop-016 is specific for Rac1 and Rac3 at concentrations of ≤5 μM. At higher concentrations, EHop-016 inhibits the close homolog Cdc42. In MDA-MB-435 cells that demonstrate high active levels of the Rac GEF Vav2, EHop-016 inhibits the association of Vav2 with a nucleotide-free Rac1(G15A), which has a high affinity for activated GEFs. EHop-016 also inhibits the Rac activity of MDA-MB-231 metastatic breast cancer cells and reduces Rac-directed lamellipodia formation in both cell lines. EHop-016 decreases Rac downstream effects of PAK1 (p21-activated kinase 1) activity and directed migration of metastatic cancer cells. Moreover, at effective concentrations (

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物理化學性質
英文名	4-N-(9-ethylcarbazol-3-yl)-2-N-(3-morpholin-4-ylpropyl)pyrimidine-2,4-diamine
中文名	EHop-016
CAS號	1380432-32-5	溶解性	---
分子量	430.54500	熔點	---
密度	---	沸點	---