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[(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl]ethyl})amine

CAS號	1401028-24-7
規格	2mg5mg	純度	98%
貨號	HY-16655	貨期	3天
品牌	Medchemexpress	庫存	需咨詢
規格	2mg5mg
純度	98%
貨號	HY-16655
貨期	3天
品牌	Medchemexpress
庫存	---
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參考價：￥1650.00 元/2mg

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貨號	品牌	純度	規格	參考價	貨期
HY-16655	Medchemexpress	98%	2mg5mg	￥1650.00元/2mg	3天

產品詳情

詳細信息(中文)：
TRV 130是_mu_-opioid受體新型配體，能誘導強G蛋白信號，pEC50值為8.1，與嗎啡活性相當，但對_beta_-arrestin招募活性弱。

詳細信息(英文)：
產品描述：TRV130TRV 130 is a novel μ-opioid receptor (MOR) G protein-biased ligand; elicits robust G protein signaling(pEC50=8.1), with potency and efficacy similar to morphine, but with far less β-arrestin recruitment and receptor internalization._x000D_ IC50 value: 8.1 (pEC50. G protein assay) [3]_x000D_ Target: MOR ligand_x000D_ in vitro: In cell-based assays, TRV130 elicits robust G protein signaling, with potency and efficacy similar to morphine, but with far less β-arrestin recruitment and receptor internalization [1]._x000D_ in vivo: In mice and rats, TRV130 is potently analgesic while causing less gastrointestinal dysfunction and respiratory suppression than morphine at equianalgesic doses [1]. Compared to morphine, TRV130 (3, 4.5mg) elicited higher peak analgesia (105, 116 seconds latency vs 75 seconds for morphine, P

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物理化學性質
英文名	[(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl]ethyl})amine
中文名	---
CAS號	1401028-24-7	溶解性	---
分子量	386.55100	熔點	---
密度	---	沸點	---